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Reishi Raised Antioxidant Markers in a Six-Month Crossover

Ganoderma lucidum is the mushroom sold as reishi or lingzhi. Folli-Activ includes it as one of ten oral ingredients. The human study that supports a firm laboratory statement is an antioxidant and liver-enzyme crossover in healthy adults. It is not a hair-count study, and the capsule was not Folli-Activ.

The six-month crossover

Chiu, Fu, Lu, Han, and colleagues enrolled 42 healthy adults, 22 men and 20 women. They took a triterpenoid- and polysaccharide-peptide-enriched Ganoderma lucidum capsule of 225 milligrams after lunch or dinner, or a placebo, for six months, then crossed over after a one-month washout. Anthropometry, blood biochemistry, and abdominal ultrasound were recorded.

The enriched mushroom raised total antioxidant capacity, reported as TEAC, from 79.33 to 84.04. Total thiols and glutathione content moved from 6 to 8.05. Antioxidant enzyme activities rose. Markers of oxidative damage fell: thiobarbituric acid reactive substances from 3.37 to 2.47, and 8-hydroxy-deoxyguanosine from 15.99 to 11.98. Liver enzymes GOT and GPT fell by 42 percent and 27 percent. These changes carried P less than 0.05. Ultrasound readings in the Ganoderma group moved from a mild fatty-liver picture at the start toward a normal picture. The outcome statement is antioxidation and a liver-enzyme change in healthy volunteers who took 225 milligrams a day of that enriched preparation for six months in a crossover.

The numbers belong to that preparation and that dose. They are a blood and ultrasound result. They are not a vertex hair count. A shopper who wants a hair-count percentage should read the pumpkin seed oil essay and the saw palmetto photograph essay. This mushroom's human paper counts antioxidant capacity, lipid peroxidation products, an oxidative DNA marker, and liver enzymes.

Sleep pharmacology, stated at the dose and the condition that were tested

Chu, Wang, Cui, Fu, and colleagues studied an aqueous extract of Ganoderma lucidum in rodents, looking for a hypnotic effect. At 80 and 120 milligrams per kilogram, the extract did not change sleep architecture in normal rats. In rats that had also received pentobarbital, the extract shortened sleep latency and increased total sleeping time, non-REM sleep, and light sleep. Flumazenil, a benzodiazepine-receptor antagonist, at 3.5 milligrams per kilogram, blocked the shorter latency and the longer sleep times. It did not block the extract's effect on delta activity during non-REM sleep. The extract also suppressed locomotor activity in normal mice.

The firm split is the same kind of split as the EGCG enzyme paper. In ordinary rats, at those two doses, sleep architecture stayed the same. In pentobarbital-treated rats, sleep lengthened, and part of that lengthening was blocked by a benzodiazepine-receptor antagonist. A page that says reishi is a sleep medicine for healthy people is ahead of this experiment. A page that says an aqueous extract changed pentobarbital sleep in rats, and left normal-rat sleep architecture unchanged at 80 and 120 milligrams per kilogram, is inside the paper.

Why the four-week human study is not used as a success

Wachtel-Galor, Tomlinson, and Benzie gave 18 healthy adults 1.44 grams a day of a commercial lingzhi for four weeks in a placebo-controlled crossover and found no significant change in their panel of antioxidant, cardiovascular, immune, inflammatory, liver, and kidney markers. Urinary antioxidant capacity rose. The investigators found no evidence of liver, kidney, or DNA toxicity. That four-week null result is why this page does not cite a one-month course as an antioxidant success. The positive human dataset used here is Chiu's six-month enriched extract at 225 milligrams. Duration and preparation differ, and the results differ. Both papers stay in the record so the positive result is not asked to cover a study that found something else.

Why reishi is in a hair formula

Oxidative damage markers are what Chiu measured, and those markers moved. Hair biology has its own stress literature, covered in a separate essay through corticosterone, Gas6, and substance P. This page does not weld those mouse follicle experiments to the Chiu blood results and call the weld a clinical trial. It keeps them as neighbours: a human antioxidant trial of enriched Ganoderma lucidum, and a separate body of work on how stress hormones hold follicle stem cells in rest. Folli-Activ includes the mushroom because the human antioxidant record is published, inside a formula whose other ingredients carry the DHT, keratin, and absorption jobs.

Packs

Reishi, named Ganoderma lucidum, is in Folli-Activ's 90-capsule bottle, brand MY NPM FOLLI-ACTIV. On this site, 1 bottle is RM169, 3 bottles are RM447, and 6 bottles are RM699 with free shipping. Checkout is by card. The six-month crossover is the study to read before expecting a blood-marker story from this mushroom. The hair essays elsewhere on the site carry the follicle endpoints.

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